Thalidomide-O-amido-PEG2-C2-NH2 TFA( Cereblon Ligand-Linker Conjugates 10 TFA | E3 Ligase Ligand-Linker Conjugates 24 TFA )

Catalog No. M26947 CAS No. 1957235-75-4

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
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10MG	119	Get Quote
25MG	200	Get Quote
50MG	296	Get Quote
100MG	444	Get Quote
200MG	671	Get Quote
500MG	1557	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

Thalidomide-O-amido-PEG2-C2-NH2 TFA
Note

Research use only, not for human use.
Brief Description

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
Description

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

Cereblon Ligand-Linker Conjugates 10 TFA | E3 Ligase Ligand-Linker Conjugates 24 TFA
Pathway

Others
Target

Other Targets
Recptor

H2 receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1957235-75-4
Formula Weight

576.482
Molecular Formula

C23H27F3N4O10
Purity

>98% (HPLC)
Solubility

In Vitro:? H2O : 150 mg/mL (260.20 mM)
SMILES

OC(=O)C(F)(F)F.NCCOCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Agut J, Sánchez JC, Sacristán A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9.

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